The examples directory of the code includes implementations of some Reference Workflows you can incorporate as provided into your application and also use to jumpstart your development of custom workflows.
A typical first use of dwave-hybrid might be to simply use the Kerberos reference sampler to solve a QUBO, as shown in Using the Framework. Next, you might tune its configurable parameters, described under Reference Workflows.
To further improve performance, you can step up from using a generic workflow to one tailored for your application and its problem. As a first step you can modify a reference workflow with existing components. After that, you can implement your own components as described in Developing New Components.